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Cholesterol‐containing non‐ionic amphiphilic polymers: synthesis and solubilization of cholesterol
Author(s) -
Cho Iwhan,
Jeong Sang Won
Publication year - 1995
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.1995.021960315
Subject(s) - amphiphile , copolymer , monomer , polymer chemistry , polymer , chemistry , cholesterol , ionic bonding , solubilization , organic chemistry , biochemistry , ion
Solubilization of cholesterol in water with cholesterol‐containing poly( N ‐vinyl‐2‐pyrrolidone) was studied. The non‐ionic amphiphilic polymers were synthesized via copolymerization of cholesterol‐based monomers with N ‐vinyl‐2‐pyrrolidone; the copolymers were dissolved isotropically in water to form hydrophobic microdomains solubilizing cholesterol efficiently. Electron micrographs revealed that the amphiphilic polymers undergo aggregational changes from random microphases to bilayers as free cholesterol is incorporated into the polymeric hydrophobic domains.