Premium
Heterochain polymers based on natural amino acids. Synthesis and enzymatic hydrolysis of regular poly(ester amide)s based on bis( L ‐phenylalanine) α,ω‐alkylene diesters and adipic acid
Author(s) -
Arabuli Natia,
Tsitlanadze George,
Edilashvili Lamara,
Kharadze Darejan,
Goguadze Tsisana,
Beridze Vakhtang,
Gomurashvili Zaza,
Katsarava Ramaz
Publication year - 1994
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.1994.021950633
Subject(s) - chemistry , hydrolysis , amide , polymer chemistry , adipic acid , potentiometric titration , adipate , acetamide , organic chemistry , amine gas treating , condensation polymer , polymer , ion
Novel biodegradable regular poly(ester amide)s were synthesized by polycondensation of p ‐toluenesulfonic acid salts of bis(phenylalanine) α,ω‐alkylene diesters ( 1 ) with bis( p ‐nitrophenyl) adipate under mild conditions in organic solvents in the presence of triethyl amine as acid acceptor. Enzymatic hydrolysis (α‐chymotrypsinolysis) of the starting salts 1 , the model bis(ester acetamide)s 2 and the obtained poly(ester amide)s 3 was investigated at 37°C and pH 8 using potentiometric titration. It was established that the hydrolysis rate increased with elongation of the α,ω‐alkylene chain. A strong noncovalent immobilization of the enzyme on the polymeric surface was observed.