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Synthesis and characterization of new hydrophobic polyurethanes for biomedical applications
Author(s) -
Marconi W.,
Martinelli A.,
Piozzi A.,
Zane D.
Publication year - 1994
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.1994.021950306
Subject(s) - alkyl , polymer , polymer chemistry , polyurethane , glass transition , hydroxymethyl , adhesion , chemistry , alkylation , extender , materials science , chemical engineering , organic chemistry , engineering , catalysis
The synthesis of new segmented polyurethanes containing as chain extender N ‐hexadecyl‐2,2‐bis(hydroxymethyl)propionamide (alone or with 1,4‐butanediol at different mole ratios) is described. The degree of hydrophobicity and the glass transition temperatures T g were found to be proportional to the alkyl chain content of the polymer. Also the amount of bonded albumin is proportional to the alkyl group content of the polymer, and platelet adhesion is remarkably lower for the 100% alkylated polymer (PEUHDA) than for the standard non‐alkylated polyurethane (PEU). This behaviour was confirmed by SEM evaluation, showing a much lower degree of activation of platelets on albuminized PEUHDA films. It was not possible to ascertain with sufficient reliability a different behaviour, with respect to platelet adhesion, of the polymers containing alkyl chains in the range 9 ÷ 50 mol‐%, due to the relatively high error of the evaluation systems.