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Dissolvable Carboxymethylcellulose Microneedles for Noninvasive and Rapid Administration of Diclofenac Sodium
Author(s) -
Silva Ana C. Q.,
Pereira Bárbara,
Lameirinhas Nicole S.,
Costa Paulo C.,
Almeida Isabel F.,
DiasPereira Patrícia,
CorreiaSá Inês,
Oliveira Helena,
Silvestre Armando J. D.,
Vilela Carla,
Freire Carmen S. R.
Publication year - 2023
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202200323
Subject(s) - transdermal , diclofenac sodium , sodium carboxymethylcellulose , diclofenac , chemistry , ex vivo , swelling , dissolution , saline , cellulose , sodium , human skin , biomedical engineering , materials science , chromatography , pharmacology , organic chemistry , composite material , in vitro , biochemistry , medicine , anesthesia , biology , genetics
The aim of this study is to prepare dissolvable biopolymeric microneedle (MN) patches composed solely of sodium carboxymethylcellulose (CMC), a water‐soluble cellulose derivative with good film‐forming ability, by micromolding technology for the transdermal delivery of diclofenac sodium salt (DCF). The MNs with ≈456 µm in height displayed adequate morphology, thermal stability up to 200 °C, and the required mechanical strength for skin insertion (>0.15 N needle −1 ). Experiments in ex vivo abdominal human skin demonstrate the insertion capability of the CMC_DCF MNs up to 401 µm in depth. The dissolution of the patches in saline buffer results in a maximum cumulative release of 98% of diclofenac after 40 min, and insertion in a skin simulant reveals that all MNs completely dissolve within 10 min. Moreover, the MN patches are noncytotoxic toward human keratinocytes. These results suggest that the MN patches produced with CMC are promising biopolymeric systems for the rapid administration of DCF in a minimally invasive manner.