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Horseradish Peroxidase‐Crosslinked Calcium‐Containing Silk Fibroin Hydrogels as Artificial Matrices for Bone Cancer Research
Author(s) -
Pierantoni Lara,
Ribeiro Viviana P.,
Costa Lígia,
Pina Sandra,
da Silva Morais Alain,
SilvaCorreia Joana,
Kundu Subhas C.,
Motta Antonella,
Reis Rui L.,
Oliveira Joaquim M.
Publication year - 2021
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202170008
Subject(s) - fibroin , horseradish peroxidase , self healing hydrogels , chemistry , calcium , silk , peroxidase , materials science , polymer chemistry , biochemistry , organic chemistry , enzyme , composite material
Front Cover : This picture shows the in situ anti‐tumor therapeutic features of the developed calcium‐containing silk fibroin hydrogels cross‐linked in the presence of calcium peroxide and horseradish peroxidase. These are characterized by the fast gelation, compacted porous microstructure and slow drug release profile. They induced the death of encapsulated osteosarcoma cells after 10 days of culture. In in vivo studies, the calciumcontaining silk fibroin hydrogels inhibited angiogenesis and induced cells death and opening up new possible applications for bone cancer treatment. This is reported by Lara Pierantoni, Viviana P. Ribeiro, Lígia Costa, Sandra Pina, Alain da Silva Morais, Joana Silva‐Correia, Subhas C. Kundu, Antonella Motta, Rui L. Reis, Joaquim M. Oliveira in article 2000425.