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Glycopolymer Based LbL Multilayer Thin Films with Embedded Liposomes
Author(s) -
Tang Jo Sing Julia,
Smaczniak Aline Debrassi,
Tepper Lucas,
Rosencrantz Sophia,
Aleksanyan Mina,
Dähne Lars,
Rosencrantz Ruben R.
Publication year - 2022
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202100461
Subject(s) - quartz crystal microbalance , glycopolymer , liposome , materials science , lipid bilayer , nanotechnology , thin film , layer by layer , bilayer , chemical engineering , chemistry , membrane , adsorption , polymer , copolymer , organic chemistry , composite material , biochemistry , engineering
Layer‐by‐layer (LbL) self‐assembly emerged as an efficient technique for fabricating coating systems for, e.g., drug delivery systems with great versatility and control. In this work, protecting group free and aqueous‐based syntheses of bioinspired glycopolymer electrolytes aredescribed. Thin films of the glycopolymers are fabricated by LbL self‐assembly and function as scaffolds for liposomes, which potentially can encapsulate active substances. The adsorbed mass, pH stability, and integrity of glycopolymer coatings as well as the embedded liposomes are investigated via whispering gallery mode (WGM) technology and quartz crystal microbalance with dissipation (QCM‐D) monitoring , which enable label‐free characterization. Glycopolymer thin films, with and without liposomes, are stable in the physiological pH range. QCM‐D measurements verify the integrity of lipid vesicles. Thus, the fabrication of glycopolymer‐based surface coatings with embedded and intact liposomes is presented.