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Photo‐Crosslinked Gelatin‐Based Hydrogel Films to Support Wound Healing
Author(s) -
Stubbe Birgit,
Mig Arn,
Van Damme Lana,
Claes Karel,
Hoeksema Henk,
Monstrey Stan,
Van Vlierberghe Sandra,
Dubruel Peter
Publication year - 2021
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202100246
Subject(s) - gelatin , methacrylamide , biocompatibility , swelling , self healing hydrogels , wound healing , acrylamide , materials science , polymer chemistry , curing (chemistry) , kinetics , chemical engineering , chemistry , polymer , composite material , copolymer , surgery , organic chemistry , medicine , physics , quantum mechanics , engineering
Gelatin is used widely in the biomedical field, among other for wound healing. Given its upper critical solution temperature, crosslinking is required. To this end, gelatin is chemically modified with different photo‐crosslinkable moieties with low (32–34%) and high (63–65%) degree of substitution (DS): gelatin‐methacrylamide (gel‐MA) and gelatin‐acrylamide (gel‐AA) and gelatin‐pentenamide (gel‐PE). Next to the more researched gel‐MA, it is especially interesting and novel to compare with other gelatin‐derived compounds for the application of wound healing. An additional comparison is made with commercial dressings. The DS is directly proportional to the mechanical characteristics and inversely proportional to the swelling capacity. Gel‐PE shows weaker mechanical properties ( G ′ < 15 kPa) than gel‐AA and gel‐MA ( G ′ < 39 and 45 kPa, respectively). All derivatives are predominantly elastic (recovery indices of 89–94%). Gel‐AA and gel‐MA show excellent biocompatibility, whereas gel‐PE shows a significantly lower initial biocompatibility, evolving positively toward day 7. Overall, gel‐MA shows to have the most potential to be applied as wound dressing. Future blending with gel‐AA to improve the curing kinetics can lead to dressings able to compete with current commercial dressings.