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Co‐Delivery of Doxorubicin and Chloroquine by Polyglycerol Functionalized MoS2 Nanosheets for Efficient Multidrug‐Resistant Cancer Therapy
Author(s) -
Xu Shaohui,
Zhong Yinan,
Nie Chuanxiong,
Pan Yuanwei,
Adeli Mohsen,
Haag Rainer
Publication year - 2021
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202100233
Subject(s) - photothermal therapy , hela , biocompatibility , doxorubicin , drug delivery , chemistry , combinatorial chemistry , biophysics , cancer cell , nanotechnology , in vitro , materials science , biochemistry , cancer , chemotherapy , organic chemistry , biology , genetics
2D MoS 2 has shown a great potential in biomedical applications, due to its superior loading capacity, photothermal property, and biodegradation. In this work, polyglycerol functionalized MoS 2 nanosheets with photothermal and pH dual‐stimuli responsive properties are used for the co‐delivery of doxorubicin and chloroquine and treatment of multidrug‐resistant HeLa (HeLa‐R) cells. The polyglycerol functionalized MoS 2 nanosheets with 80 nm average size show a high biocompatibility and loading efficiency (≈90%) for both drugs. The release of drugs from the nanosheets at pH 5.5 is significantly promoted by laser irradiation leading to efficient destruction of incubated HeLa‐R cells. In vitro evaluation shows that the designed nanoplatform has a high ability to kill HeLa‐R cells. Confocal experiments demonstrate that the synthesized drug delivery system enhances the cellular uptake of DOX via folic acid targeting ligand. Taking advantage of the combined properties including biocompatibility and targeting ability as well as high loading capacity and photothermal release, this multifunctional nanosystem is a promising candidate for anticancer therapy.