Premium
Gelatin‐Based Versus Alginate‐Based Hydrogels: Providing Insight in Wound Healing Potential
Author(s) -
Ionescu Oana Maria,
Mig Arn,
Minsart Ma,
Van Hoorick Jasper,
Gardikiotis Ioannis,
Caruntu IrinaDraga,
Giusca Simona Eliza,
Van Vlierberghe Sandra,
Profire Lenuta
Publication year - 2021
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202100230
Subject(s) - wound healing , gelatin , self healing hydrogels , in vivo , swelling , biomedical engineering , chemistry , wound dressing , materials science , polymer chemistry , surgery , composite material , medicine , biochemistry , microbiology and biotechnology , biology
Wound dressings under the form of films constituted of modified alginate (methacrylated alginate – AlgMA) versus a gelatine derivative containing norbornene functionalities (GelNB) are developed and evaluated for their moisturizing effects, followed by further in vivo testing to assay their wound healing potential. The gel fraction results shows that AlgMA and GelNB films displayed a high crosslinking efficiency while the swelling assay reveals a stronger water uptake capacity for AlgMA films compared to GelNB and to commercial dressing AquacelAg, used as positive control. Referring to the in vivo wound healing effect, the GelNB films not only exhibit proper healing properties, yet is higher to the AquacelAg, while the AlgMA films exhibit similar wound healing effect as the positive control. On a microscopic level, the healing phases (from inflammation to proliferation and contraction) are present for both materials, yet at a faster rate for the GelNB films, which is in line with the macroscopic findings. These results provide data which support that GelNB films outperform AlgMA films, but both can be used for wound healing applications.