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Supercritical Fluid‐Based Decellularization Technologies for Regenerative Medicine Applications
Author(s) -
Kim BeomSeok,
Kim JeongUk,
So KyoungHa,
Hwang Nathaniel S.
Publication year - 2021
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202100160
Subject(s) - decellularization , supercritical fluid , regenerative medicine , supercritical fluid extraction , tissue engineering , biomedical engineering , nanotechnology , biological fluids , chemistry , materials science , engineering , chromatography , biochemistry , organic chemistry , cell
Supercritical fluid‐based extraction technologies are currently being increasingly utilized in high purity extract products for food industries. In recent years, supercritical fluid‐based extraction technology is transformed in biomaterials process fields to be further utilized for tissue engineering and other biomedical applications. In particular, supercritical fluid‐based decellularization protocols have great advantage over the conventional decellularization as it may allow preservation of extracellular matrix components and structures. In this review, the latest technological development utilizing the supercritical fluid‐based decellularization for regenerative medicine is introduced.