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Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications
Author(s) -
Chu Wenlin,
Nie Mingxi,
Ke Xiang,
Luo Jun,
Li Jianshu
Publication year - 2021
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202100109
Subject(s) - self healing hydrogels , nanotechnology , regeneration (biology) , biocompatible material , biomedical engineering , materials science , dual role , chemistry , medicine , polymer chemistry , combinatorial chemistry , biology , microbiology and biotechnology
Injectable dual crosslinking hydrogels hold great promise to improve therapeutic efficacy in minimally invasive surgery. Compared with prefabricated hydrogels, injectable hydrogels can be implanted more accurately into deeply enclosed sites and repair irregularly shaped lesions, showing great applicable potential. Here, the current fabrication considerations of injectable dual crosslinking hydrogels are reviewed. Besides, the progress of the hydrogels used in corresponding applications and emerging challenges are discussed, with detailed emphasis in the fields of bone and cartilage regeneration, wound dressings, sensors and other less mentioned applications for their more hopeful employments in clinic. It is envisioned that the further development of the injectable dual crosslinking hydrogels will catalyze their innovation and transformation in the biomedical field.