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Poly(amino ester)‐Based Polymers for Gene and Drug Delivery Systems and Further Application toward Cell Culture System
Author(s) -
Hyun Jiyu,
Eom Jiin,
Song Jihun,
Seo Inwoo,
Um Soong Ho,
Park Kyung Min,
Bhang Suk Ho
Publication year - 2021
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202100106
Subject(s) - transdermal , polymer , drug delivery , gene delivery , synthetic polymer , nanotechnology , delivery system , chemistry , drug , combinatorial chemistry , materials science , organic chemistry , biomedical engineering , biochemistry , gene , pharmacology , biology , genetic enhancement , medicine
Various synthetic polymers based on poly(amino ester) (PAE) are suggested as candidates for gene and drug delivery owing to their pH‐responsiveness, which contributes to efficient delivery performance. PAE‐based pH‐responsive polymers are more biodegradable and hydrophilic than other types of pH‐responsive polymers. The functionality of PAE‐based polymers can be reinforced by using different chemical modifications to improve the efficiency of gene and drug delivery. Additionally, PAE‐based polymers are used in many ways in the biomedical field, such as in transdermal delivery and stem cell culture systems. Here, the recent novel PAE‐based polymers designed for gene and drug delivery systems along with their further applications toward adult stem cell culture systems are reviewed. The synthetic tactics are contemplated and pros and cons of each type of polymer are analyzed, and detailed examples of the different types are analyzed.