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From Folding to Assembly: Functional Supramolecular Architectures of Peptides Comprised of Non‐Canonical Amino Acids
Author(s) -
Misra Rajkumar,
RudnickGlick Safra,
AdlerAbramovich Lihi
Publication year - 2021
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202100090
Subject(s) - supramolecular chemistry , folding (dsp implementation) , amino acid , nanotechnology , chemistry , peptide , non canonical , nanostructure , biocompatibility , combinatorial chemistry , materials science , molecule , biology , biochemistry , organic chemistry , engineering , microbiology and biotechnology , electrical engineering
The engineering of biological molecules is the fundamental concept behind the design of complex materials with desirable functions. Over the last few decades, peptides and proteins have emerged as useful building blocks for well‐defined nanostructures with controlled size and dimensions. Short peptides in particular have received much attention due to their inherent biocompatibility, lower synthetic cost, and ease of tunability. In addition to the diverse self‐assembling properties of short peptides comprising coded amino acids and their emerging applications in nanotechnology, there is now growing interest in the properties of peptides composed of non‐canonical amino acids. Such non‐natural oligomers have been shown in recent years to form well‐defined secondary structures similar to natural proteins, with the ability to self‐assemble to generate a wide variety of nanostructures with excellent biostability. This review describes recent events in the development of supramolecular assemblies of peptides composed completely of non‐coded amino acids and their hybrid analogues. Special attention is paid to understanding the supramolecular assemblies at the atomic level and to considering their potential applications in nanotechnology.