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Aliphatic Polyester‐Based Materials for Enhanced Cancer Immunotherapy
Author(s) -
Chin Ai Lin,
Wang Xiaoqian,
Tong Rong
Publication year - 2021
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202100087
Subject(s) - plga , polyester , glycolic acid , drug delivery , immunotherapy , cancer , lactic acid , immune system , chemistry , nanotechnology , materials science , medicine , nanoparticle , organic chemistry , immunology , biology , bacteria , genetics
Poly(lactic acid) (PLA) and its copolymer, poly(lactic‐ co ‐glycolic acid) (PLGA), based aliphatic polyesters have been extensively used for biomedical applications, such as drug delivery system and tissue engineering, thanks to their biodegradability, benign toxicity, renewability, and adjustable mechanical properties. A rapidly growing field of cancer research, the development of therapeutic cancer vaccines or treatment modalities is aimed to deliver immunomodulatory signals that control the quality of immune responses against tumors. Herein, the progress and applications of PLA and PLGA are reviewed in delivering immunotherapeutics to treat cancers.