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A novel Vancomycin‐Functionalized‐Magnetic Graphene Composite for Use as a Near‐Infrared‐Induced Synergistic Chemo‐Photothermal Antibacterial
Author(s) -
Zhang Wenjing,
Shan Suyan,
Fan Jinyi,
Yuan Feng,
Lawson Tom,
Kong Lingdan,
Hu Rongdang,
Liu Yong
Publication year - 2021
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202100082
Subject(s) - photothermal therapy , staphylococcus aureus , antibacterial activity , nanocomposite , graphene , bacteria , vancomycin , microbiology and biotechnology , antibiotics , pathogenic bacteria , composite number , chitosan , photothermal effect , materials science , antibacterial agent , chemistry , nanotechnology , biology , composite material , organic chemistry , genetics
Antibiotic‐resistant bacterial strains are a major cause of disease. They continue to remain a challenge in the clinic particularly in the vision system. For example, infectious endophthalmitis is a major blind‐causing disease caused by bacteria. A highly efficient synergistic antibacterial treatment that uses a photothermal antibacterial therapeutic with a chemo‐antibacterial therapeutic in a multifunctional nanocomposite is reported. It is prepared by immobilizing vancomycin onto the surface of a magnetic chitosan‐graphene (VCM‐MCG) composite. An antibacterial effect is achieved when VCM‐MCG is applied. This effect is enhanced when the nanocomposites are irradiated with a near‐infrared laser. Growth of gram‐positive methicillin‐resistant Staphylococcus aureus and gram‐negative Escherichia coli bacteria are suppressed efficiently. Such a composite can help manage the control of pathogenic bacteria growth in the clinic.