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Calcium Signaling Regulates Valvular Interstitial Cell Alignment and Myofibroblast Activation in Fast‐Relaxing Boronate Hydrogels
Author(s) -
Ma Hao,
Macdougall Laura J.,
GonzalezRodriguez Andrea,
Schroeder Megan E.,
Batan Dilara,
Weiss Robert M.,
Anseth Kristi S.
Publication year - 2020
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202070025
Subject(s) - myofibroblast , self healing hydrogels , mechanotransduction , chemistry , crosstalk , calcium , ethylene glycol , transient receptor potential channel , viscoelasticity , calcium signaling , fibrosis , microbiology and biotechnology , biophysics , receptor , materials science , biochemistry , polymer chemistry , medicine , biology , organic chemistry , physics , optics , composite material
Front Cover : Valvular interstitial cell (VIC) alignment and myofibroblast activation are investigated using a Poly(ethylene glycol) (PEG) based fastrelaxing boronate hydrogel with tunable viscoelasticity. VIC spreading and alignment correlates with higher extents of stress relaxation, signaling through transient receptor potential vanilloid 4 (TRPV4) calcium channel. A potential crosstalk between viscoelasticity, calcium signaling, and mechanotransduction is proposed, which may provide insights for treatment of valvular tissue fibrosis. This cover art depicts the different cellular behaviors when VICs are encapsulated in 3D hydrogel systems with different viscoelasticity. This is reported by Hao Ma, Laura J. Macdougall, Andrea GonzalezRodriguez, Megan E. Schroeder, Dilara Batan, Robert M. Weiss, and Kristi S. Anseth in article 2000268.