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Guanidinylated Amphiphilic Polycarbonates with Enhanced Antimicrobial Activity by Extending the Length of the Spacer Arm and Micelle Self‐Assembly
Author(s) -
Cho Chloe A.,
Liang Chao,
Perera Janesha,
Brimble Margaret A.,
Swift Simon,
Jin Jianyong
Publication year - 2020
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202070014
Subject(s) - amphiphile , antimicrobial , micelle , polymer , chemistry , polymer chemistry , aqueous solution , chemical engineering , organic chemistry , copolymer , engineering
Front Cover : The authors conducted research on antimicrobial polymer structure‐activity relationships (SARs) based on their platform of guanidine containing aliphatic biodegradable polycarbonates with varying amphiphilicity and charge densities. These guanidinylated polycarbonates exhibited potent antimicrobial activity, but with low hemolytic activity. Furthermore, these polymers exhibited the ability to self‐assemble and present micelle‐like nanostructure due to their intrinsic amphiphilic macromolecular structure. This cover art depicts the antimicrobial polymer strands and their aggregation as nanoparticles in an aqueous environment, and the polymer micelles contacting the microbes in suspension, causing the membrane disruption that is the basis of the antimicrobial properties. This is reported by Chloe A. Cho, Chao Liang, Janesha Perera, Margaret A. Brimble, Simon Swift, Jianyong Jin in article 2000065.