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Porous Polymer Scaffolds based on Cross‐Linked Poly‐EGDMA and PLA: Manufacture, Antibiotics Encapsulation, and In Vitro Study
Author(s) -
Chesnokov Sergey A.,
Aleynik Diana Ya.,
Kovylin Roman S.,
Yudin Vladimir V.,
Egiazaryan Tatevik A.,
Egorikhina Marfa N.,
Zaslavskaya Maya I.,
Rubtsova Yulia P.,
Gusev Sergey A.,
Mlyavykh Sergey G.,
Fedushkin Igor L.
Publication year - 2021
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202000402
Subject(s) - ethylene glycol dimethacrylate , polymer , cyclohexanol , materials science , porosity , polymer chemistry , chemical engineering , polymerization , chemistry , methacrylic acid , organic chemistry , composite material , catalysis , engineering
Abstract Porous polymer materials derived from poly(ethylene glycol dimethacrylate) (poly‐EGDMA) and antibiotic containing polylactide (PLA) are obtained for the first time. Porous poly‐EGDMA monoliths with a system of open interconnected pores are synthesized by a visible light‐induced radical polymerization of EGDMA in the presence of 70 wt% of porogenic agent, e.g., 1‐butanol, 1‐hexanol, 1‐octanol, or cyclohexanol. The porosity of the obtained polymers is 75–78%. A modal pore size depends on the nature of the porogen and varies from 0.5 µm (cyclohexanol) to 12 µm (1‐butanol). The polymer matrix made with 1‐butanol features the presence of pores ranging from 1 to 100 µm. The pore surface of poly‐EGDMA matrices is inlayered with poly‐D,L‐lactide ( M n 23 × 10 3 Da, PDI 1.31). The PLA‐modified poly‐EGDMA retains a porous structure that is similar to the initial poly‐EGDMA but with improved strength characteristics. The presence of antibiotic containing PLA ensures a high and continuous antibacterial activity of the hybrid polymeric material for 7 days. The nontoxicity of all the porous matrices studied makes them promising for clinical tests as osteoplastic materials.