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Development of a Mechanically Strong Nondegradable Protein Hydrogel with a Sponge‐Like Morphology
Author(s) -
Wang Ya,
Fu Rongzhan,
Ma Xiaoxuan,
Li Xian,
Fan Daidi
Publication year - 2021
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202000396
Subject(s) - self healing hydrogels , biocompatibility , bovine serum albumin , interconnectivity , porosity , biomedical engineering , materials science , chemistry , chemical engineering , composite material , polymer chemistry , chromatography , medicine , artificial intelligence , computer science , engineering , metallurgy
Protein‐based hydrogels are important functional materials with many potential applications. However, the relatively small pore size and poor mechanical properties substantially limit their application. Here a superporous bovine serum albumin (BSA) hydrogel is prepared with high porosity and interconnectivity by using BSA and 1,2,7,8‐diepoxyoctane (DEO). The equilibrium water contents of hydrogels can reach 76.5%. Moreover, the BSA hydrogels show excellent mechanical properties and excellent deformation recoverability, with a maximum compression modulus of 50 MPa at 75% strain and no residual strain generated after 500 cyclic compression tests. The resulting BSA hydrogel has excellent biocompatibility for cell adherence and is nonbiodegradable for 40 weeks. More importantly, the BSA hydrogel exhibits excellent hemostatic ability, with hemostatic times in a rabbit ear artery and rabbit liver of 33 and 28 s, respectively. Therefore, BSA hydrogels have potential applications as painless nonadherent wound dressings and implant materials for plastic surgery.