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Multifunctional Sutures with Temperature Sensing and Infection Control
Author(s) -
Houshyar Shadi,
Bhattacharyya Amitava,
Khalid Asma,
Rifai Aaqil,
Dekiwadia Chaitali,
Kumar G. Sathish,
Tran Phong A.,
Fox Kate
Publication year - 2021
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202000364
Subject(s) - polycaprolactone , materials science , graphene , fibrous joint , ultimate tensile strength , biomedical engineering , surgery , composite material , nanotechnology , medicine , polymer
The next‐generation sutures should provide in situ monitoring of wound condition such as temperature while reducing surgical site infection during wound closure. In this study, functionalized nanodiamond (FND) and reduced graphene oxide (rGO) into biodegradable polycaprolactone (PCL) are incorporated to develop a new multifunctional suture with such capabilities. Incorporation of FND and rGO into PCL enhances its tensile strength by about 43% and toughness by 35%. The sutures show temperature sensing capability in the range of 25–40 °C based on the shift in zero‐splitting frequency of the nitrogen‐vacancy (NV – ) centers in FND via optically detected magnetic resonance, paving the way for potential detection of infection or excessive inflammation in healing wounds. The suture surface readily coats with antibiotics to reduce bacterial infection risk to the wounds. The new suture thus is promising in monitoring and supporting wound closure.