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Antibacterial Hybrid Hydrogels
Author(s) -
Cao Zhongming,
Luo Yue,
Li Zhaoyang,
Tan Lei,
Liu Xiangmei,
Li Changyi,
Zheng Yufeng,
Cui Zhenduo,
Yeung Kelvin Wai Kwok,
Liang Yanqin,
Zhu Shengli,
Wu Shuilin
Publication year - 2021
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202000252
Subject(s) - self healing hydrogels , biocompatibility , antibacterial activity , nanotechnology , materials science , chemistry , polymer , antibacterial agent , bacteria , antibiotics , polymer chemistry , organic chemistry , composite material , biochemistry , biology , genetics
Bacterial infectious diseases and bacterial‐infected environments have been threatening the health of human beings all over the world. In view of the increased bacteria resistance caused by overuse or improper use of antibiotics, antibacterial biomaterials are developed as the substitutes for antibiotics in some cases. Among them, antibacterial hydrogels are attracting more and more attention due to easy preparation process and diversity of structures by changing their chemical cross‐linkers via covalent bonds or noncovalent physical interactions, which can endow them with various specific functions such as high toughness and stretchability, injectability, self‐healing, tissue adhesiveness and rapid hemostasis, easy loading and controlled drug release, superior biocompatibility and antioxidation as well as good conductivity. In this review, the recent progress of antibacterial hydrogel including the fabrication methodologies, interior structures, performances, antibacterial mechanisms, and applications of various antibacterial hydrogels is summarized. According to the bacteria‐killing modes of hydrogels, several representative hydrogels such as silver nanoparticles‐based hydrogel, photoresponsive hydrogel including photothermal and photocatalytic, self‐bacteria‐killing hydrogel such as inherent antibacterial peptides and cationic polymers, and antibiotics‐loading hydrogel are focused on. Furthermore, current challenges of antibacterial hydrogels are discussed and future perspectives in this field are also proposed.