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Benchmarking the Performance of Electropolymerized Poly(3,4‐ethylenedioxythiophene) Electrodes for Neural Interfacing
Author(s) -
Nikiforidis Georgios,
Wustoni Shofarul,
Routier Cyril,
Hama Adel,
Koklu Anil,
Saleh Abdulelah,
Steiner Nadia,
Druet Victor,
Fiumelli Hubert,
Inal Sahika
Publication year - 2020
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202000215
Subject(s) - interfacing , microelectrode , capacitance , materials science , conductive polymer , nanotechnology , electrode , cyclic voltammetry , electrochemistry , capacitive sensing , polymer , chemistry , electrical engineering , computer science , composite material , engineering , computer hardware
The development of electronics adept at interfacing with the nervous system is an ever‐growing effort, leading to discoveries in fundamental neuroscience applied in clinical setting. Highly capacitive and electrochemically stable electronic materials are paramount for these advances. A systematic study is presented where copolymers based on 3,4‐ethylenedioxythiophene (EDOT) and its hydroxyl‐terminated counterpart (EDOTOH) are electropolymerized in an aqueous solution in the presence of various counter anions and additives. Amongst the conducting materials developed, the copolymer p(EDOT‐ ran ‐EDOTOH) doped with perchlorate in the presence of ethylene glycol shows high specific capacitance (105 F g −1 ), and capacitance retention (85%) over 1000 galvanostatic charge–discharge cycles. A microelectrode array‐based on this material is fabricated and primary cortical neurons are cultured therein for several days. The microelectrodes electrically stimulate targeted neuronal networks and record their activity with high signal‐to‐noise ratio. The stability of charge injection capacity of the material is validated via long‐term pulsing experiments. While providing insights on the effect of additives and dopants on the electrochemical performance and operational stability of electropolymerized conducting polymers, this study highlights the importance of high capacitance accompanied with stability to achieve high performance electrodes for biological interfacing.