Premium
Robust Grafting of Polyionenes: New Potent and Versatile Antimicrobial Surfaces
Author(s) -
Bernardi Sarah,
Renault Margareth,
Malabirade Antoine,
Debou Nabila,
Leroy Jocelyne,
Herry JeanMarie,
Guilbaud Morgan,
Arluison Veronique,
BellonFontaine MarieNoelle,
Carrot Geraldine
Publication year - 2020
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202000157
Subject(s) - grafting , contact angle , chemistry , antimicrobial , adhesion , covalent bond , polymer chemistry , polymer , fourier transform infrared spectroscopy , surface modification , x ray photoelectron spectroscopy , polymerization , chemical engineering , materials science , combinatorial chemistry , organic chemistry , engineering
Polyionenes (PI) with stable positive charges and tunable hydrophobic spacers in the polymer backbone, are shown to be particularly efficient regarding antimicrobial properties. This effect can be modulated since it increases with the length of hydrophobic spacers, i.e., the number of methylene groups between quaternary ammoniums. Now, to further explore these properties and provide efficient antimicrobial surfaces, polyionenes should be grafted onto materials. Here a robust grafting strategy to covalently attach polyionenes is described. The method consisted in a sequential surface chemistry procedure combining polydopamine coating, diazonium‐induced polymerization, and polyaddition. To the best of knowledge, grafting of PI onto surfaces is not reported earlier. All chemical steps are characterized in detail via various surface analysis techniques (FTIR, X‐ray photoelectron spectroscopy, contact angle, and surface energy measurements). The antibacterial properties of polyionene‐grafted surfaces are then studied through bacterial adhesion experiments consisting in enumeration of adherent bacteria (total and viable cultivable cells). PI‐grafted surfaces are showed to display effective and versatile bacteriostatic/bactericidal properties associated with a proadhesive effect.