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Ion Exchange Controlled Drug Release from Polymerized Ionic Liquids
Author(s) -
Claus Johanna,
Eickner Thomas,
Grabow Niels,
Kragl Udo,
Oschatz Stefan
Publication year - 2020
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202000152
Subject(s) - chemistry , self healing hydrogels , cationic polymerization , drug delivery , controlled release , ionic bonding , polymerization , drug , ion exchange , chloride , polymer chemistry , chemical engineering , ion , organic chemistry , polymer , pharmacology , medicine , engineering
In this work ion functionalized hydrogels as potent drug delivery systems are presented. The ion functionalization of the hydrogel enables the retention of ionic drug molecules and thus a reduction of burst release effects. Timolol maleate in combination with polymerized anionic 3‐sulfopropylmethacrylate potassium and ibuprofen combined with cationic poly‐[2‐(methacryloyloxy)ethyl] trimethylammonium chloride are investigated in respect to their drug release profile. The results are showing an ion exchange depending release behavior instead of a diffusion‐controlled drug release as it is known from common drug delivery systems. Furthermore, the suitability of such hydrogels for standard methods for sterilization is investigated.