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Injectable Polypeptide Hydrogel Depot System for Assessment of the Immune Response–Inducing Efficacy of Sustained Antigen Release Alone
Author(s) -
Asai Daisuke,
Fukuda Tadashi,
Morokuma Kazunori,
Funamoto Daiki,
Yamaguchi Yuko,
Mori Takeshi,
Katayama Yoshiki,
Shibayama Keigo,
Nakashima Hideki
Publication year - 2019
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201970026
Subject(s) - avidity , antigen , immune system , toxoid , titer , depot , chemistry , antibody , immunology , immunization , medicine , archaeology , history
Front Cover : Implantation of injectable non‐immunogenic hydrogel depots comprising‐recombinantly synthesized polypeptide together with antigenic toxoid in mice showed that sustained antigen release alone is sufficient to induce high titers of antibodies with high avidity. This model mimics reallife infections, and the results should be helpful for rational design of nextgeneration vaccines. This is reported by Daisuke Asai, Tadashi Fukuda, Kazunori Morokuma, Daiki Funamoto, Yuko Yamaguchi, Takeshi Mori, Yoshiki Katayama, Keigo Shibayama, and Hideki Nakashima in article 1900167.