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Drug‐Loaded Elastin‐Like Polypeptide–Collagen Hydrogels with High Modulus for Bone Tissue Engineering
Author(s) -
Pal Pallabi,
Nguyen Quynh C.,
Benton Angela H.,
Marquart Mary E.,
Janorkar Amol V.
Publication year - 2019
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201970025
Subject(s) - elastin , self healing hydrogels , tissue engineering , chemistry , biophysics , biomedical engineering , polymer chemistry , pathology , biology , medicine
Back Cover : Doxycycline and rhBMP‐2 loaded collagen‐elastin‐like polypeptide hydrogel is developed with high elastic modulus and anti‐microbial properties. The hydrogel has interconnected, macroporous, three‐dimensional open porous architecture. This architecture supported human adipose‐derived stem cell attachment and proliferation evidenced through rhodamine/DAPI and live/dead staining. Mineralization is observed as bright red stained particles and indicated the terminal osteogenic differentiation of cells. This is reported by Pallabi Pal, Quynh C. Nguyen, Angela H. Benton, Mary E. Marquart, and Amol V. Janorkar in article 1900142.