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O‐Mannosylation Affords a Glycopeptide Hydrogel with Inherent Antibacterial Activities against E. coli via Multivalent Interactions between Lectins and Supramolecular Assemblies
Author(s) -
Li Jing,
Liang Shufeng,
Yan Yufei,
Tian Xin,
Li Xinming
Publication year - 2019
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201970023
Subject(s) - glycopeptide , chemistry , supramolecular chemistry , mannose , lectin , adhesion , scaffold , pseudomonas aeruginosa , biochemistry , bacteria , biology , organic chemistry , molecule , antibiotics , medicine , biomedical engineering , genetics
Front Cover : By mimicking multivalent glycosystems in nature for bacterial binding, a new glycopeptide scaffold with mannose modification is developed, which can perform supramolecular self‐assembly, and present multiple mannose ligands on its self‐assembled structure. Relying on multivalent carbohydrate–lectin interactions, the glycopeptide hydrogel can interact with E. coli , and result in bacterial adhesion, membrane disruption and subsequent cell death. This is reported by Jing Li, Shufeng Liang, Yufei Yan, Xin Tian, and Xinming Li in article 1900124.