Premium
Progress in Articular Cartilage Tissue Engineering: A Review on Therapeutic Cells and Macromolecular Scaffolds
Author(s) -
Zhao Zhongyi,
Fan Changjiang,
Chen Feng,
Sun Yutai,
Xia Yujun,
Ji Aiyu,
Wang DongAn
Publication year - 2020
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201900278
Subject(s) - cartilage , articular cartilage , regeneration (biology) , tissue engineering , biomedical engineering , chemistry , anatomy , microbiology and biotechnology , medicine , pathology , osteoarthritis , biology , alternative medicine
Repair and regeneration of articular cartilage lesions have always been a major challenge in the medical field due to its peculiar structure (e.g., sparsely distributed chondrocytes, no blood supply, no nerves). Articular cartilage tissue engineering is considered as one promising strategy to achieve reconstruction of cartilage. With this perspective, the articular cartilage tissue engineering has been widely studied. Here, the recent progress of articular cartilage tissue engineering is reviewed. The ad hoc therapeutic cells and growth factors for cartilage regeneration are summarized and discussed. Various types of bio/macromolecular scaffolds together with their pros and cons are also reviewed and elaborated.