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Biadhesive Peptides for Assembling Stainless Steel and Compound Loaded Micro‐Containers
Author(s) -
Apitius Lina,
Buschmann Sven,
Bergs Christian,
Schönauer David,
Jakob Felix,
Pich Andrij,
Schwaneberg Ulrich
Publication year - 2019
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201900125
Subject(s) - polycaprolactone , materials science , scanning electron microscope , fabrication , chemistry , nanotechnology , biomedical engineering , polymer , composite material , medicine , alternative medicine , pathology
Abstract Biadhesive peptides (peptesives) are an attractive tool for assembling two chemically different materials—for example, stainless steel and polycaprolactone (PCL). Stainless steel is used in medical stents and PCL is used as a biodegradable polymer for fabrication of tissue growth scaffolds and drug delivering micro‐containers. Biadhesive peptides are composed of two domains (e.g., dermaseptin S1 and LCI) with different material‐binding properties that are separated through a stiff peptide‐spacer. The peptesive dermaseptin S1‐domain Z‐LCI immobilizes antibiotic‐loaded PCL micro‐containers on stainless steel surfaces. Immobilization is visualized by microscopy and field emission scanning electron microscopy analysis and released antibiotic from the micro‐containers is confirmed through growth inhibition of Escherichia coli cells.