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Dual Therapy Coating on Micro/Nanoscale Porous Polyetheretherketone to Eradicate Biofilms and Accelerate Bone Tissue Repair
Author(s) -
Deng Lijun,
He Xianhua,
Xie Kenan,
Xie Lu,
Deng Yi
Publication year - 2019
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201800376
Subject(s) - peek , biofilm , alkaline phosphatase , simvastatin , biomedical engineering , materials science , chemistry , tobramycin , coating , osseointegration , implant , adhesion , nanotechnology , bacteria , biochemistry , enzyme , composite material , surgery , medicine , antibiotics , pharmacology , biology , gentamicin , genetics , polymer
Defective osteogenesis and latent infections continue to be two major issues in the therapy of bone tissue regeneration. In this study, a unique hierarchically micro/nanoscale‐architecture is first proposed and produced on polyetheretherketone (PEEK). Besides, a “simvastatin‐PLLA film‐tobramycin microspheres” delivery system is subsequently fabricated to endow the PEEK implant with osteogenic and antibacterial capabilities. In vitro antibacterial evaluations confirm that the decorated PEEK scaffolds possess excellent resistance against planktonic/adherent bacteria. In vitro cell attachment/proliferation, lactate dehydrogenase (LDH) content, alkaline phosphatase (ALP) activity, calcium mineral deposition experiments, and real‐time PCR analysis all exhibit that the superior proliferation rate and osteo‐differentiation potential of MC3T3‐E1 pre‐osteoblasts are presented on the PEEK samples with dual functional decoration. In the mouse calvarial defect model, the micro‐CT and histological results demonstrate that our scaffolds display a remarkable bone forming capability. Generally, the PEEK scaffolds co‐endowed with simvastatin and tobramycin microspheres possess great potential in clinics.