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Graphene Oxide Immobilized PLGA‐polydopamine Nanofibrous Scaffolds for Growth Inhibition of Colon Cancer Cells
Author(s) -
Chen Minmin,
Jiang Suwei,
Zhang Feng,
Li Linlin,
Hu Hailiang,
Wang Hualin
Publication year - 2018
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201800321
Subject(s) - plga , chemistry , nanofiber , scaffold , nanotechnology , graphene , oxide , biophysics , chemical engineering , materials science , biomedical engineering , nanoparticle , organic chemistry , medicine , engineering , biology
Abstract Graphene oxide (GO)/poly (lactide‐co‐glycolic acid) (PLGA) scaffolds have promising applications in the biomedical field. However, greater attention is focused on the incorporated system and its applications in normal cells. In this work, a novel GO immobilized PLGA nanofibrous scaffold assisted by polydopamine (PLGA‐PDA‐GO) is developed for growth inhibition of HT‐29 colon cancer cells. The interactions between GO and PDA are attributed to a π–π conjugate interaction and electrostatic attraction. In addition to the enhancement of thermal stability and mechanical strength, the surface roughness, hydrophilicity, and electro‐activity of the scaffolds are significantly improved by immobilization of GO. The scaffolds show good inhibition of HT‐29, and immobilized GO is observed to be in contact with but not internalized in HT‐29 cells. The cytotoxicity mechanism of scaffolds toward HT‐29 is attributed to intracellular activated reactive oxygen species that result from the physical interaction of the sharp GO edges and electrical signals of π–π stacking between PDA and GO.