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Fabrication of PEOT/PBT Nanofibers by Atmospheric Pressure Plasma Jet Treatment of Electrospinning Solutions for Tissue Engineering
Author(s) -
Grande Silvia,
Cools Pieter,
Asadian Mahtab,
Guyse Joachim,
Onyshchenko Iuliia,
Declercq Heidi,
Morent Rino,
Hoogenboom Richard,
Geyter Nathalie
Publication year - 2018
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201800309
Subject(s) - nanofiber , electrospinning , polybutylene terephthalate , polyethylene terephthalate , x ray photoelectron spectroscopy , polymer chemistry , chemical engineering , materials science , atmospheric pressure , atmospheric pressure plasma , oxide , chloroform , methanol , polymer , nuclear chemistry , chemistry , polyester , nanotechnology , organic chemistry , composite material , plasma , oceanography , geology , engineering , physics , quantum mechanics
This study focuses on the enhanced electrospinning of 300‐Polyethylene oxide‐polyethylene oxide terephthalate/polybutylene terephthalate (PEOT/PBT). An atmospheric pressure plasma jet for liquid treatment is applied to a solution with 9 w/v% PEOT/PBT dissolved in either chloroform (CHCl 3 ), CHCl 3 + N,N‐dimethylformamide (DMF), CHCl 3 + methanol (MeOH), or CHCl 3 + hexafluoroisopropanol (HFIP). For all conditions, the plasma‐treated samples present better‐quality fibers: less or no‐beads and uniform fiber diameter distribution. Except for CHCl 3 + DMF, no significant changes to the material bulk are detected, as shown with size exclusion chromatography (SEC). X‐ray photoelectron spectroscopy (XPS) spectra performed on nanofibers record an increase in C–C bonds for the CHCl 3 + DMF combination upon plasma modification, while a shift and slight increase in oxygen‐containing bonds is found for the CHCl 3 + HFIP and CHCl 3 + MeOH mixtures. MTT assay shows no‐cytotoxic effects for CHCl 3 + DMF, while a better cellular adhesion is found on nanofibers from CHCl 3 + MeOH and CHCl 3 + HFIP. Among the examined additives, MeOH is preferable as it produces beadless electrospun nanofibers with an average diameter of 290 ± 100 nm without causing significant changes to the final nanofiber surface properties.