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Injectable Hydrogels as Unique Platforms for Local Chemotherapeutics‐Based Combination Antitumor Therapy
Author(s) -
Yu Shuangjiang,
He Chaoliang,
Chen Xuesi
Publication year - 2018
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201800240
Subject(s) - combination therapy , self healing hydrogels , drug delivery , medicine , radiation therapy , pharmacology , chemotherapy , drug , systemic therapy , cancer therapy , cancer , chemistry , nanotechnology , materials science , organic chemistry , breast cancer
Different strategies of chemotherapeutics‐based combination cancer therapy have presented enhanced antitumor efficiency and are widely used in clinical cancer treatments. However, several drawbacks of the systems for systemic administration, including low drug accumulation at tumor sites and significant systemic side effects limit their efficacy and application in the clinic. Local drug co‐delivery systems based on injectable hydrogels may have considerable advantages, such as a facile drug‐delivery procedure, targeted delivery of antitumor agents to tumor sites in a sustained manner, and markedly reduced systemic toxicities. Thus, in recent years, these systems have received increasing attention and consequently various injectable hydrogels have been tested as platforms for local chemotherapeutics‐based combination antitumor therapy. In this review, the focus is on recent advances in injectable hydrogel‐based drug co‐delivery systems for local combination antitumor therapy, including multiple chemotherapeutics combination therapy, chemo‐immunotherapy, chemo‐radiotherapy, and hyperthermia‐chemotherapy. Moreover, the rationale and preparation of local co‐delivery systems are summarized and discussed.