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RAFT Emulsion Polymerization as a Platform to Generate Well‐Defined Biocompatible Latex Nanoparticles
Author(s) -
Gurnani Pratik,
SanchezCano Carlos,
Abraham Kristin,
XandriMonje Helena,
Cook Alexander B.,
Hartlieb Matthias,
Lévi Francis,
Dallmann Robert,
Perrier Sébastien
Publication year - 2018
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201800213
Subject(s) - emulsion polymerization , biodistribution , nanoparticle , polymerization , raft , chain transfer , chemistry , chemical engineering , reversible addition−fragmentation chain transfer polymerization , particle size , dynamic light scattering , materials science , nanotechnology , polymer chemistry , radical polymerization , polymer , organic chemistry , in vitro , biochemistry , engineering
Current approaches to generate core–shell nanoparticles for biomedical applications are limited by factors such as synthetic scalability and circulatory desorption of cytotoxic surfactants. Developments in controlled radical polymerization, particularly in dispersed states, represent a promising method of overcoming these challenges. In this work, well‐defined PEGylated nanoparticles are synthesized using reversible addition fragmentation chain transfer emulsion polymerization to control particle size and surface composition and were further characterized with light scattering, electron microscopy, and size exclusion chromatography. Importantly, the nanoparticles are found to be tolerated both in vitro and in vivo, without the need for any purification after particle synthesis. Pharmacokinetic and biodistribution studies in mice, following intraperitoneal injection of the nanoparticles, reveal a long (>76 h) circulation time and accumulation in the liver.