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Graphene‐Oxide‐Decorated Microporous Polyetheretherketone with Superior Antibacterial Capability and In Vitro Osteogenesis for Orthopedic Implant
Author(s) -
Ouyang Ling,
Deng Yi,
Yang Lei,
Shi Xiuyuan,
Dong Taosheng,
Tai Youyi,
Yang Weizhong,
Chen ZhiGang
Publication year - 2018
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201800036
Subject(s) - peek , graphene , microporous material , materials science , alkaline phosphatase , osteoblast , adhesion , antibacterial activity , chemistry , chemical engineering , substrate (aquarium) , osseointegration , composite material , in vitro , nanotechnology , implant , organic chemistry , polymer , biochemistry , bacteria , medicine , surgery , engineering , enzyme , oceanography , biology , geology , genetics
Due to its similar elastic modulus of human bones, polyetheretherketone (PEEK) has been considered as an excellent cytocompatible material. However, the bioinertness, poor osteoconduction, and weak antibacterial activity of PEEK limit its wide applications in clinics. In this study, a facile strategy is developed to prepare graphene oxide (GO) modified sulfonated polyetheretherketone (SPEEK) (GO‐SPEEK) through a simple dip‐coating method. After detailed characterization, it is found that the GO closely deposits on the surface of PEEK, which is attributed to the π–π stacking interaction between PEEK and GO. Antibacterial tests reveal that the GO‐SPEEK exhibits excellent suppression toward Escherichia coli . In vitro cell attachment, growth, differentiation, alkaline phosphatase activity, quantitative real‐time polymerase chain reaction analyses, and calcium mineral deposition all illustrate that the GO‐SPEEK substrate can significantly accelerate the proliferation and osteogenic differentiation of osteoblast‐like MG‐63 cells compared with those on PEEK and SPEEK groups. These results suggest that the GO‐SPEEK has an improved antibacterial activity and cytocompatibility in vitro, showing that the developed GO‐SPEEK has a great potential as the bioactive implant material in bone tissue engineering.