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Spherical and Worm‐Like Micelles from Fructose‐Functionalized Polyether Block Copolymers
Author(s) -
Majdanski Tobias C.,
Pretzel David,
Czaplewska Justyna A.,
Vitz Jürgen,
Sungur Pelin,
Höppener Stephanie,
Schubert Stephanie,
Schacher Felix H.,
Schubert Ulrich S.,
Gottschaldt Michael
Publication year - 2018
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201700396
Subject(s) - micelle , ethylene glycol , copolymer , fructose , chemistry , nile red , dynamic light scattering , peg ratio , polymer chemistry , glycidyl methacrylate , fluorescence , organic chemistry , nanoparticle , polymer , materials science , nanotechnology , aqueous solution , physics , finance , quantum mechanics , economics
Abstract This paper presents the synthesis and characterization of d ‐fructose modified poly(ethylene glycol) (Fru‐PEG) and fructose modified poly(ethylene glycol)‐ block ‐poly(ethyl hexyl glycidyl ether) (Fru‐PEG‐ b ‐PEHG) that are both prepared by initiation with isopropyliden protected fructose, followed by deprotection of the sugar. The block copolymers are self‐assembled into micelles, and are subsequently characterized by cryo‐TEM and dynamic light scattering. The fluorescent dye Nile red is encapsulated as a model hydrophobic compound and fluorescent marker to perform initial uptake tests with breast cancer cells. The uptake of sugar and nonsugar decorated micelles is compared.