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Design of Polymeric Culture Substrates to Promote Proangiogenic Potential of Stem Cells
Author(s) -
Kwon ByeongJu,
Wang Xintong,
Kang MiLan,
You Jin,
Lee ShinJeong,
Kim Won Shik,
Yoon Youngsup,
Park JongChul,
Sung HakJoon
Publication year - 2018
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201700340
Subject(s) - regenerative medicine , stem cell , tissue engineering , microbiology and biotechnology , self healing hydrogels , biomaterial , chemistry , nanotechnology , biomedical engineering , biology , materials science , engineering , organic chemistry
Stem cells are a promising cell source for regenerative medicine due to their differentiation and self‐renewal capacities. In the field of regenerative medicine and tissue engineering, a variety of biomedical technologies have been tested to improve proangiogenic activities of stem cells. However, their therapeutic effect is found to be limited in the clinic because of cell loss, senescence, and insufficient therapeutic activities. To address this type of issue, advanced techniques for biomaterial synthesis and fabrication have been approached to mimic proangiogenic microenvironment and to direct proangiogenic activities. This review highlights the types of polymers and design strategies that have been studied to promote proangiogenic activities of stem cells. In particular, scaffolds, hydrogels, and surface topographies, as well as insight into their underlying mechanisms to improve proangiogenic activities are the focuses. The strategy to promote angiogenic activities of hMSCs by controlling substrate repellency is introduced, and the future direction is proposed.