Premium
Chitosan‐Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery
Author(s) -
Bai Xiaoyu,
Bao Zixian,
Bi Shichao,
Li Yang,
Yu Xiaoping,
Hu Shihao,
Tian Meiping,
Zhang Xin,
Cheng Xiaojie,
Chen Xiguang
Publication year - 2018
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201700305
Subject(s) - self healing hydrogels , chitosan , chemistry , drug delivery , bovine serum albumin , phosphate buffered saline , drug carrier , drug , controlled release , chromatography , polymer chemistry , nuclear chemistry , biochemistry , pharmacology , materials science , nanotechnology , organic chemistry , medicine
A series of thermo/pH sensitive N ‐succinyl hydroxybutyl chitosan (NSHBC) hydrogels with different substitution degrees of succinyl are prepared for drug delivery. Rheology analysis shows that the gelation temperature of NSHBC hydrogels is 3.8 °C higher than that of hydroxybutyl chitosan (HBC) hydrogels. A model drug bovine serum albumin (BSA) is successfully loaded and released. NSHBC hydrogels show excellent pH sensitivity drug release behaviors. After incubation for 24 h, 93.7% of BSA is released from NSHBC hydrogels in phosphate buffer saline (PBS) (pH 7.4), which is significantly greater than that of 24.6% at pH 3.0. In contrast, the release rate of BSA from HBC is about 70.0% at pH 3.0 and 7.4. Thus, these novel hydrogels have the prominent merits of high adaptability to soluble drugs and pH sensitivity triggered release, indicating that NSHBC hydrogels have promising applications in oral drug delivery.