Premium
Development of a Dual‐Functional Hydrogel Using RGD and Anti‐VEGF Aptamer
Author(s) -
Zhao Nan,
Battig Mark R.,
Xu Ming,
Wang Xiuli,
Xiong Na,
Wang Yong
Publication year - 2017
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201700201
Subject(s) - aptamer , biomaterial , chemistry , self healing hydrogels , nucleic acid , ethylene glycol , vegf receptors , tissue engineering , nanotechnology , biophysics , biochemistry , materials science , biomedical engineering , microbiology and biotechnology , biology , cancer research , engineering , organic chemistry
Synthetic molecular libraries hold great potential to advance the biomaterial development. However, little effort is made to integrate molecules with molecular recognition abilities selected from different libraries into a single biomolecular material. The purpose of this work is to incorporate peptides and nucleic acid aptamers into a porous hydrogel to develop a dual‐functional biomaterial. The data show that an anti‐integrin peptide can promote the attachment and growth of endothelial cells in a 3D porous poly(ethylene glycol) hydrogel and an antivascular endothelial growth factor aptamer can sequester and release VEGF of high bioactivity. Importantly, the dual‐functional porous hydrogel enhances the growth and survival of endothelial cells. This work demonstrates that molecules selected from different synthetic libraries can be integrated into one system for the development of novel biomaterials.