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In Vitro and In Vivo Characterization of Biodegradable Reactive Isocyanate‐Terminated Three‐Armed‐ and Hyperbranched Block Copolymeric Tissue Adhesives
Author(s) -
Bochyńska Agnieszka I.,
Hannink Gerjon,
Rongen Jan J.,
Grijpma Dirk W.,
Buma Pieter
Publication year - 2017
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201700125
Subject(s) - adhesive , materials science , isocyanate , in vivo , curing (chemistry) , meniscus , ultimate tensile strength , composite material , biomedical engineering , polymer chemistry , polyurethane , medicine , physics , microbiology and biotechnology , incidence (geometry) , layer (electronics) , optics , biology
Tissue adhesives are an attractive class of biomaterials, which can serve as a treatment for meniscus tears. In this study, physicochemical and adhesive properties of novel biodegradable three‐armed‐ and hyperbranched block copolymeric adhesives are evaluated. Additionally, their degradation in vitro and in vivo, and the tissue reaction after subcutaneous injection in rats are assessed. The developed adhesives have sufficient adhesive strength to meniscus tissue after curing (66–88 kPa). Networks based on the three‐armed adhesive have tensile properties that are in the same range as human meniscus. After 26 weeks, networks based on the hyperbranched adhesive show a faster mass loss (25.4%) compared to networks prepared from the three‐armed ones (5.5%). Both adhesives induce an inflammatory reaction, however, no necrosis and only initial toxic effects on peripheral tissues are observed. The proposed materials are suitable candidates for the use as resorbable tissue adhesives for meniscus repair.