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A Polymer Chemistry Point of View on Mucoadhesion and Mucopenetration
Author(s) -
Schattling Philipp,
Taipaleenmäki Essi,
Zhang Yan,
Städler Brigitte
Publication year - 2017
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201700060
Subject(s) - mucoadhesion , zeta potential , context (archaeology) , chemistry , ethylene glycol , nanomedicine , nanotechnology , drug delivery , polymer science , polymer , drug carrier , organic chemistry , materials science , nanoparticle , paleontology , biology
Although oral is the preferred route of administration of pharmaceutical formulations, the long‐standing challenge for medically active compounds to efficiently cross the mucus layer barrier limits its wider applicability. Efforts in nanomedicine to overcome this hurdle consider mucoadhesive and mucopenetrating drug carriers by selectively designing (macromolecular) building blocks. This review highlights and critically discusses recent strategies developed in this context including poly(ethylene glycol)‐based modifications, cationic and thiolated polymers, as well as particles with high charge density, zeta‐potential shifting ability, or mucolytic properties. The latest advances in ex vivo test platforms are also reviewed.