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Time‐Controllable Lipophilic‐Drug Release System Designed by Loading Lipid Nanoparticles into Polysaccharide Hydrogels
Author(s) -
Racine Lisa,
Guliyeva Aynur,
Wang Irène,
LarretaGarde Véronique,
AuzélyVelty Rachel,
Texier Isabelle
Publication year - 2017
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201700045
Subject(s) - self healing hydrogels , nanoparticle , swelling , diffusion , chemistry , polymer , chemical engineering , controlled release , particle (ecology) , particle size , drug carrier , nanotechnology , biophysics , drug delivery , polymer chemistry , materials science , organic chemistry , physics , oceanography , geology , biology , engineering , thermodynamics
A hybrid hydrogel composed of solid lipid nanoparticles (LNPs) entrapped within chemically cross‐linked carboxymethylcellulose (CMC) is developed to achieve localized and sustained release of lipophilic drugs. The analysis of LNP stability as well as the hydrogel swelling and mechanical properties confirm the successful incorporation of particles up to a concentration of 50% w/w CMC . The initial LNP release rate can be prolonged by increasing the particle diameter from 50 to 120 nm, while the amount of long‐term release can be adjusted by tailoring the particle surface charge or the cross‐linking density of the polymer. After 30 d, 58% of 50 nm diameter negatively charged LNPs escape from the matrix while only 17% of positively charged nanoparticles are released from materials with intermediate cross‐linking density. A mathematical diffusion model based on Fick's second law is efficient to predict the diffusion of the particles from the hydrogels.