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Enhanced Self‐Renewal and Accelerated Differentiation of Human Fetal Neural Stem Cells Using Graphene Oxide Nanoparticles
Author(s) -
Kim Jin,
Yang Kisuk,
Lee Jong Seung,
Hwang Yong Hwa,
Park HyunJi,
Park Kook In,
Lee Dong Yun,
Cho SeungWoo
Publication year - 2017
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201600540
Subject(s) - neurosphere , neural stem cell , neurogenesis , stem cell , biocompatibility , graphene , nanotechnology , nanoparticle , microbiology and biotechnology , cellular differentiation , materials science , chemistry , biophysics , adult stem cell , biology , biochemistry , gene , metallurgy
Graphene oxide (GO) has received increasing attention in bioengineering fields due to its unique biophysical and electrical properties, along with excellent biocompatibility. The application of GO nanoparticles (GO‐NPs) to engineer self‐renewal and differentiation of human fetal neural stem cells (hfNSCs) is reported. GO‐NPs added to hfNSC culture during neurosphere formation substantially promote cell‐to‐cell and cell‐to‐matrix interactions in neurospheres. Accordingly, GO‐NP‐treated hfNSCs show enhanced self‐renewal ability and accelerated differentiation compared to untreated cells, indicating the utility of GO in developing stem cell therapies for neurogenesis.