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Bioprinting Using Mechanically Robust Core–Shell Cell‐Laden Hydrogel Strands
Author(s) -
Mistry Pritesh,
Aied Ahmed,
Alexander Morgan,
Shakesheff Kevin,
Bennett Andrew,
Yang Jing
Publication year - 2017
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201600472
Subject(s) - extracellular matrix , extrusion , shell (structure) , nanotechnology , core (optical fiber) , 3d bioprinting , tissue engineering , cell function , self healing hydrogels , materials science , cell , chemistry , biomedical engineering , composite material , engineering , polymer chemistry , biochemistry
The strand material in extrusion‐based bioprinting determines the microenvironments of the embedded cells and the initial mechanical properties of the constructs. One unmet challenge is the combination of optimal biological and mechanical properties in bioprinted constructs. Here, a novel bioprinting method that utilizes core–shell cell‐laden strands with a mechanically robust shell and an extracellular matrix‐like core has been developed. Cells encapsulated in the strands demonstrate high cell viability and tissue‐like functions during cultivation. This process of bioprinting using core–shell strands with optimal biochemical and biomechanical properties represents a new strategy for fabricating functional human tissues and organs.