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Evaluation of the Biocompatibility of Polypyrrole Implanted Subdurally in GAERS
Author(s) -
Bauquier Sebastien H.,
McLean Karen J.,
Jiang Jonathan L.,
Boston Ray C.,
Lai Alan,
Yue Zhilian,
Moulton Simon E.,
Halliday Amy J.,
Wallace Gordon,
Cook Mark J.
Publication year - 2017
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201600334
Subject(s) - glial fibrillary acidic protein , gliosis , implant , biocompatibility , h&e stain , medicine , polypyrrole , pathology , chemistry , surgery , immunohistochemistry , polymer , organic chemistry , polymerization
This blinded controlled prospective randomized study investigates the biocompatibility of polypyrrole (PPy) polymer that will be used for intracranial triggered release of anti‐epileptic drugs (AEDs). Three by three millimeters PPy are implanted subdurally in six adult female genetic absence epilepsy rats from Strasbourg. Each rat has a polymer implanted on one side of the cortex and a sham craniotomy performed on the other side. After a period of seven weeks, rats are euthanized and parallel series of coronal sections are cut throughout the implant site. Four series of 15 sections are histological (hematoxylin and eosin) and immunohistochemically (neuron‐specific nuclear protein, glial fibrillary acidic protein, and anti‐CD68 antibody) stained and evaluated by three investigators. The results show that implanted PPy mats do not induce obvious inflammation, trauma, gliosis, and neuronal toxicity. Therefore the authors conclude the PPy used offer good histocompatibility with central nervous system cells and that PPy sheets can be used as intracranial, AED delivery implant.