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Multifunctional Surface Modification: Facile and Flexible Reactivity toward a Precisely Controlled Biointerface
Author(s) -
Yuan RueiHung,
Wu ChihYu,
Tung HsingYing,
Hsieh HungPin,
Li YiJye,
Chiang YuChih,
Chen HsienYeh
Publication year - 2017
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201600322
Subject(s) - biointerface , biomolecule , surface modification , reactivity (psychology) , functional polymers , materials science , combinatorial chemistry , polymer , chemistry , nanotechnology , chemical engineering , organic chemistry , copolymer , medicine , alternative medicine , pathology , engineering
A multicomponent functional polymer is synthesized to support specific reactivity for successful conjugation with the vast array of functionality present in biological systems and the flexibility to conjugate biomolecules without requiring additional modification to install a terminal functional group. The multifunctional surface is realized using a novel coating composed of distinct N ‐hydroxysuccinimide (NHS) ester and benzoyl functionalities, which can provide accessibility to both the NHS ester‐amine coupling reaction and the photochemically induced benzophenone crosslinking reaction, respectively. In addition, the multifunctional polymer is fabricated and transformed to form nanoscale colloids through the solvent displacement of a water/DMF system due to solubility characteristics of the resulting polymer with high polarity. A facile and efficient fabrication approach using the multifunctional nanocolloid is thus demonstrated to create a drug carrier by installing paclitaxel and folic acid for targeted cancer therapy.