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Polypeptide‐Based Conjugates as Therapeutics: Opportunities and Challenges
Author(s) -
Zagorodko Oleksandr,
ArroyoCrespo Juan José,
Nebot Vicent J.,
Vicent María J.
Publication year - 2017
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201600316
Subject(s) - drug delivery , conjugate , nanotechnology , computer science , chemistry , computational biology , biochemical engineering , combinatorial chemistry , engineering , biology , materials science , mathematics , mathematical analysis
Synthetic polypeptides or polyamino acids have become a useful and multifunctional platform in advanced drug delivery studies. Nonetheless, the full potential of these systems has yet to be achieved. The final structure of polypeptide conjugates and their in vivo behavior are dependent on an extraordinarily complex pattern of interconnected physico‐chemical and structural parameters, making sophisticated directional design of such systems difficult and often unachievable. In this review, the authors aim to discuss the role of these parameters in the successful design of different drug delivery architectures and to delineate some basic correlations between structure, properties, and the biological behavior of polypeptide‐based conjugates.