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Super‐Anticoagulant Heparin‐Mimicking Hydrogel Thin Film Attached Substrate Surfaces to Improve Hemocompatibility
Author(s) -
He Min,
Cui Xiaofei,
Jiang Huiyi,
Huang Xuelian,
Zhao Weifeng,
Zhao Changsheng
Publication year - 2017
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201600281
Subject(s) - membrane , chemical engineering , heparin , materials science , self healing hydrogels , chemistry , partial thromboplastin time , antithrombin , anticoagulant drug , porosity , thrombin time , substrate (aquarium) , polymer chemistry , thrombin , coagulation , composite material , biochemistry , platelet , psychology , oceanography , psychiatry , biology , engineering , immunology , geology
In this study, heparin‐mimicking hydrogel thin films are covalently attached onto poly(ether sulfone) membrane surfaces to improve anticoagulant property. The hydrogel films display honeycomb‐like porous structure with well controlled thickness and show long‐term stability. After immobilizing the hydrogel films, the membranes show excellent anticoagulant property confirmed by the activated partial thromboplastin time values exceeding 600 s. Meanwhile, the thrombin time values increase from 20 to 61 s as the sodium allysulfonate proportions increase from 0 to 80 mol%. In vitro investigations of protein adsorption and blood‐related complement activation also confirm that the membranes exhibit super‐anticoagulant property. Furthermore, gentamycin sulfate is loaded into the hydrogel films, and the released drug shows significant inhibition toward E. coli bacteria. It is believed that the surface attached heparin‐mimicking hydrogel thin films may show high potential for the applications in various biological fields, such as blood contacting materials and drug loading materials.