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Understanding Polymer‐Cell Attachment
Author(s) -
Venturato Andrea,
MacFarlane Gillian,
Geng Jin,
Bradley Mark
Publication year - 2016
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201600253
Subject(s) - polymer , copolymer , monomer , polymer chemistry , dispersity , polymerization , acrylate , chemistry , hela , adhesion , radical polymerization , cell adhesion , materials science , chemical engineering , cell , organic chemistry , biochemistry , engineering
The development of polymeric materials with cell adhesion abilities requires an understanding of cell–surface interactions which vary with cell type. To investigate the correlation between cell attachment and the nature of the polymer, a series of random and block copolymers composed of 2‐(dimethylamino)ethyl acrylate and ethyl acrylate are synthesized through single electron transfer living radical polymerization. The polymers are synthesized with highly defined and controlled monomer compositions and exhibited narrow polydispersity indices. These polymers are examined for their performance in the attachment and growth of HeLa and HEK cells, with attachment successfully modeled on monomer composition and polymer chain length, with both cell lines found to preferentially attach to moderately hydrophobic functional materials. The understanding of the biological‐material interactions assessed in this study will underpin further investigations of engineered polymer scaffolds with predictable cell binding performance.