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Polymeric Nanogels with Tailorable Degradation Behavior
Author(s) -
Chen Yinan,
Steenbergen Mies J.,
Li Dandan,
Dikkenberg Joep B.,
Lammers Twan,
Nostrum Cornelus F.,
Metselaar Josbert M.,
Hennink Wim E.
Publication year - 2016
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201600031
Subject(s) - methacrylamide , nanogel , methacrylate , polymer chemistry , hydrolysis , chemistry , drug delivery , degradation (telecommunications) , 2 hydroxyethyl methacrylate , nanoparticle , materials science , chemical engineering , copolymer , polymer , organic chemistry , nanotechnology , acrylamide , engineering , telecommunications , computer science
The aim of this study is to design a polymeric nanogel system with tailorable degradation behavior. To this end, hydroxyethyl methacrylate‐oligoglycolates‐derivatized poly(hydroxypropyl methacrylamide) (pHPMAm‐Gly‐HEMA) and hydroxyethyl methacrylamide‐oligoglycolates‐derivatized poly(hydroxyethyl methacrylamide) (pHEMAm‐Gly‐HEMAm) are synthesized and characterized. pHEMAm‐Gly‐HEMAm shows faster hydrolysis rates of both carbonate and glycolate esters than the same ester groups of pHPMAm‐Gly‐HEMA. pHEMAm‐Gly‐HEMAm nanogels have tailorable degradation kinetics from 24 h to more than 4 d by varying their crosslink densities. It is shown that the release of a loaded macromolecular model drug is controlled by degradation of nanogels. The nanogels show similar cytocompatibility as PLGA nanoparticles and are therefore considered to be attractive systems for drug delivery.